- 81' ↑ Chimy Ávila ↓ Cucho Hernández
- 81' ↑ Lucas Ahijado ↓ Nacho Vidal
- 81' ↑ Thiago Borbas ↓ Federico Viñas
- 71' ↑ Isco ↓ Giovani Lo Celso
- 70' ↑ Nelson Deossa ↓ Sofyan Amrabat
- 64' ↑ Haissem Hassan ↓ Thiago Fernández
- 64' ↑ Kwasi Sibo ↓ Santiago Colombatto
- 63' ↑ Rodrigo Riquelme ↓ Pablo Fornals
- 62' ↑ Marc Roca ↓ Antony
- 58' Golo · Cucho Hernández (ass: Abde Ezzalzouli)
- 55' ↑ Santi Cazorla ↓ Nicolás Fonseca
- 54' VAR · Federico Viñas
- 45' Golo · Abde Ezzalzouli (ass: Antony)
- 22' Golo · Cucho Hernández (ass: Pablo Fornals)